Friday July 1 2022

This collaborative proposal grows out of the investigators’ shared interest in the genetic exploration of endophenotypes as a powerful strategy for understanding the genetics of schizophrenia. Over the past several years, the investigators at the 7 Consortium sites have planned the proposed study. The 7 participating sites are Harvard University, Mount Sinai School of Medicine, University of Colorado Health Sciences Center, University of Pennsylvania, University of California, Los Angeles, University of California, San Diego and University of Washington. Each site has a successful record of peer-reviewed funding for family and genetic studies of major neuropsychiatric disorders.

This proposal describes studies designed to measure 6 carefully selected endophenotypes in schizophrenia patients and their relatives (see Response #3). Analyses will determine whether these endophenotypes in schizophrenia patients and relatives reflect the influence of a single common gene, or multiple genes. Specific statistical strategies will then utilize these endophenotype measures in concert with a genome scan in patients and family members, to identify genes regulating these 6 schizophrenia endophenotypes. The remainder of this proposal describes the rationale for selecting the 6 specific endophenotypes, and the strategies for their use in understanding the genetics of schizophrenia.
  © 2003-2022 SIStat. All rights reserved. If your have comments or questions, please email SIStat.